ABSTRACT
AIDS related malignancies have gradually decreased after the introduction of highly active antiretroviral therapy (HAART). Nevertheless, non-Hodgkin's lymphoma is still a major malignancy in resource limited countries that have difficulty supplying HAART, and same holds true for Korea. We report a case of non-Hodgkin's lymphoma involving the heart in a Korean AIDS patient, who presented with sudden arrhythmia and superior vena cava syndrome. He was diagnosed with AIDS in 2008, but refused to receive HAART. Immunohistologic findings were compatible diffuse large B cell lymphoma, and futher studies demonstrated involvement of the liver, adrenal gland, heart, and pericardiac space. HAART was initiated and non Hodgkin's lymphoma was successfully managed with intensive chemotherapy. This is the first cardiac involvement non Hodgkin's lymphoma in AIDS patients in Korea.
Subject(s)
Humans , Adrenal Glands , Antiretroviral Therapy, Highly Active , Arrhythmias, Cardiac , Heart , Korea , Liver , Lymphoma, B-Cell , Lymphoma, Non-Hodgkin , Superior Vena Cava SyndromeABSTRACT
BACKGROUND: Lung cancer-associated hypercalcemia is one of the most disabling and life-threatening paraneoplastic desorders. Humoral hypercalcemia is responsible for most lung cancer-associated hypercalcemia. Patients with hypercalcemia are usually in the advenced atage with obvious bulky tumor and carry a poor prognosis. MATERIALS AND METHODS: Total 29 patients satisfied the following criteria: histologically proven primary lung cancer, corrected calcium level> or =10.5 mg/dL, and symptons which could possibly be attributed to hypercalcemia. In this retrospective study, we evalluated the various clinical aspects of hypercalcemia, in relation to cancer stage, histologic cell type, mass size, bone metastasis, performance status, and other possible characteristics RESULTS: Total 29 lung cancer patients with hypercalcemia were studied, and most of them had squamous cell carcinoma in their histologic finding. The incidence of hypercalcemia was significantly higher between 50 and 69 years of age, and in the advancement of cancer stage. Although serum calcium level showed positive correlation with mass size, performance statusm and bone ore frequent in the patients with higher serum calcium level. There were no differences in effectiveness among therapeutic regimens. Hypercalcemia was more frequently in the later stage of disease than during the initial diagnosis of lung cancer. Most of the patients died within 1 month after development of hypercalcemia. CONCLUSION: We concluded that hypercalcemia in lung cancer is related to extremely poor prognosis, and may be one of the causes of drath and should be treated aggressively to prevent sudden deterioration or death.
Subject(s)
Humans , Calcium , Carcinoma, Bronchogenic , Carcinoma, Squamous Cell , Diagnosis , Hypercalcemia , Incidence , Lung , Lung Neoplasms , Neoplasm Metastasis , Prognosis , Retrospective StudiesABSTRACT
No abstract available.
ABSTRACT
No abstract available.
ABSTRACT
We were experienced Duchenne type muscular dystrophy occuring in 3 brothers among 6 siblings. In all cases, the clinical symtoms were started at about 6 years old age, And diagnosis was easily confirmed by clinical symptoms and laboratory examination with muscle biopsy. We report with brief review of the literature.